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冯晓明
冯晓明
青年千人、中国医学科学院北京协和医学院研究员
领域:T细胞发育和功能
  

个人简介

男,国家第四批“青年千人计划”入选者,中国医学科学院北京协和医学院研究员。

个人经历

1998-2003  华中科技大学同济医学院,临床医学学士

2003-2008  中国医学科学院血液学研究所,内科学(科研型)博士

2008-2012  美国 Wistar研究所,博士后

2012-至今  中国医学科学院血液学研究所,PI

研究方向

1.  T细胞发育和功能

2.  抗肿瘤(白血病)免疫

3.  干细胞向功能性免疫细胞分化

学术成果

代表论著:

1.     Feng X, Wang H, Takata H, Day TJ, Willen J, Hu H. Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol. 2011;12:544-50

2.     Feng X, Ippolito G, Tian L, Karla W, Oh S, Sambandam A, Willen J, Bunte MR, Caton JA, Bhandoola A, Tucker WP, Hu H. Foxp1 is an essential transcription regulator for the generation of quiescent naive T cells during thymocytes development. Blood. 2010;115(3):510-8.

3.     Feng XM, Liu Na, Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC. Regulation of the class II and class I MHC Pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008;367(3):553-9.

4.     Feng XM, Chen XL, Liu N, Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC. IL-27 up-regulates MHC class II expression in primary human endothelial cells through induction of CIITA. Hum Immunol. 2007;68(12):965-72.

5.     Ji YR, Yang ZX, Han ZB, Meng L, Liang L, Feng XM, Yang SG, Chi Y, Chen DD, Wang YW, Han ZC. Mesenchymal Stem Cells Support Proliferation and Terminal Differentiation of B Cells. Cell Physiol Biochem. 2012;30(6):1526-1537.

6.     Chen F, Zhou K, Zhang L, Ma F, Cui J, Chen D, Feng X, Lu S, Han Z. Mesenchymal stem cells induce granulocytic differentiation of acute promyelocytic leukemic cells via IL-6 and MEK/ERK pathways. Stem cells Dev. 2012 (in revision)

7.     Liu N, Feng X, Fang Z, Lu S, Lu M, Han Z. Identification of genes regulated by Nanog which is involved in ES cells pluripotency and early differentiation. J Cell Biochem. 2008;104(6):2348-62.

8.     Liu N, Lu M, Feng X, Ma F, Fang Z, Tian X, Ren Q, Zhang L, Liu B, Huang P, Liu L, Han Z. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition. J Cell Biochem. 2009;106(6):1041-7.

9.     Chen X, Xu J, Chen Z, Zhou Z, Feng X, Zhou Y, Ren Q, Yang R, Han ZC.  Interferon-gamma +874A/T and interleukin-4 intron3 VNTR gene polymorphisms in Chinese patients with idiopathic thrombocytopenic purpura. Eur J Haematol. 2007;79:191-7.