二维码
联系我们
谢震
谢震
青年千人、清华大学国家实验室生物信息学部特别研究员
领域:合成生物学元件、模块构建
  工作经历
2011.12 至今,清华大学信息科学与技术国家实验室,特别研究员
2010.07 - 2011.12,麻省理工学院, 生物工程系,计算机科学与人工智能实验室,博士后
2006.10 - 2010.07,哈佛大学,FAS系统生物学中心,博士后

教育背景

2006,内华达大学拉斯维加斯分校,生物系,博士
2001,山东农业大学,园艺学院,硕士
1998,山东农业大学,园艺学院,学士

研究方向

合成生物学元件、模块构建;基因合成与基因回路组装自动化;以基因回路为基础的基因治疗与细胞治疗方法研究;生物分子信号感应处理系统与细胞自动控制系统;


主要学术论文

• Schmid-Burgk JL, Xie Z, Frank S, Virreira Winter S, Mitschka S, Kolanus W, Murray A, Benenson Y.Rapid hierarchical assembly of medium-size DNA cassettes.(2012)Nucleic Acids Res.Epub ahead of print

• Leisner M, Bleris L, Lohmueller J, Xie Z and Benenson Y. MicroRNA circuits for transcriptional logic. (2012) Methods Molecular Biology. 813:169-86.
• Xie Z., Wroblewska L., Prochazka L., Weiss R. and Benenson Y. (2011) Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science 333(6047):1307-11. 
• Bleris L., Xie Z., Glass D., Adadey A., Sontag E. and Benenson Y. (2011) Synthetic incoherent feed-forward circuits show adaptation to the amount of their genetic template. Molecular Systems Biology 7, 519.
• Leisner M., Bleris L., Lohmueller J., Xie Z. and Benenson Y. (2010) Rationally designed logic integration of regulatory signals in mammalian cells. Nature Nanotechnology 5(9), 666-70. 
• Xie Z., Liu S.J., Bleris L. and Benenson Y. (2010) Logic integration of mRNA signals by an RNAi-based molecular computer. Nucleic Acids Research 38, 2692-2701. 
• Xie Z.†, Zhang Z.L.†, Hanzlik S., Cook E. and Shen Q.J. (2007) Salicylic acid inhibits gibberellin-induced alpha-amylase expression and seed germination via a pathway involving an abscisic-acid-inducible WRKY gene. Plant Molecular Biology 64(3), 293-303. 
• Xie Z.†, Zhang Z.L.†, Zou X., Yang G., Komatsu S. and Shen Q.J. (2006) Interactions of two abscisic-acid induced WRKY genes in repressing gibberellin signaling in aleurone cells. Plant Journal 46, 231-242. 
• Xie Z., Ruas P. and Shen Q.J. (2005) Regulatory networks of phytohormone abscisic acid. Vitamins and Hormones 72, 235-269. (Book Chapter)
• Xie Z.†, Zhang Z.L.†, Zou X., Huang J., Ruas P., Thompson D. and Shen Q.J. (2005) Annotations and functional analyses of the rice WRKY gene superfamily reveal positive and negative regulators of abscisic acid signaling in aleurone cells. Plant Physiology 137, 176-189. 
• Zhang Z.L.†, Xie Z.†, Zou X., Casaretto J., Ho T.D. and Shen Q.J. (2004) A rice WRKY gene encodes a transcriptional repressor of the gibberellin signaling pathway in aleurone cells. Plant Physiology 134, 1500-1513.